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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
NMDA receptors outside CNS and their subunit composition
 Hotovec, Matěj ; Kolcheva, Marharyta (advisor) ; Horáková, Olga (referee)
N-Methyl-D-Aspartate receptors (NMDARs) are a type of ionotropic glutamate receptor that is widely present in the central nervous system and in lesser numbers in other parts of the body, including the gastrointestinal tract. NMDARs play a crucial role in various physiological and pathological processes in the CNS, including synaptic plasticity, learning and memory, and excitotoxic damage. The role of NMDARs outside the CNS is still under investigation. This thesis aims to confirm the presence of NMDARs in the gastrointestinal tract and their subunit composition. Subunit specific NMDAR modulators showed effect on spontaneous phasic activity of ileum, indirectly confirming the presence of GluN1, GluN2A-D and GluN3 subunits. Attempt at direct evidence of protein expression by immunolabeling with monoclonal antibodies against NMDAR subunits was unsuccessful.
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Ileální stravitelnost vápníku v závislosti na tvorbě skořápky
 Jaroš, Jaromír
The aim of the study was to observe changes in illeal digestibility of calcium and phosphorus during shell formation. The experiment was conducted on 350 Lohmann LSL-Classic hybrids laying whiteshelled eggs. At the time of the experiment, layers were fed with 115 g per layer per day of DeHeus N1 Power with the supplement of 0,5 % of chromium dioxide. Five groups were established. T1 (5–6 hours after laying), T2 (7–8 hours after laying), T3 (9–10 hours after laying), T4 (11–12 hours after laying), T5 (13–14 hours after laying). Six replications for each group were performed. All laying hens were housed in the same conditions in enriched cages. The ileal digestibility of calcium and phosphorus was determined by the indicator method. Within the first 10 hours after laying the last egg, the digestibility of calcium stayed unchanged at 61–62 %. A statistically significant increase in digestibility up to 75 % occurred approximately 12 hours after the lay in the T4 group. The digestibility of the phosphorus was fluctuating across all groups. Extension of the study throughout the whole process of eggshell formation would show a more comprehensive view of the issue.
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Léčba benigních ureterointestinálních striktur wallstentem
Urban, Michael ; Zachoval, Roman ; Univerzita Karlova.
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